| First Author | Chen M | Year | 2011 |
| Journal | Cancer Cell | Volume | 20 |
| Issue | 2 | Pages | 173-86 |
| PubMed ID | 21840483 | Mgi Jnum | J:176062 |
| Mgi Id | MGI:5288271 | Doi | 10.1016/j.ccr.2011.07.013 |
| Citation | Chen M, et al. (2011) Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell 20(2):173-86 |
| abstractText | Hyperactivation of the PI 3-kinase/AKT pathway is a driving force of many cancers. Here we identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor suppressor. We show that Phlpp1-loss causes neoplasia and, on partial Pten-loss, carcinoma in mouse prostate. This genetic setting initially triggers a growth suppressive response via p53 and the Phlpp2 ortholog, and reveals spontaneous Trp53 inactivation as a condition for full-blown disease. Surprisingly, the codeletion of PTEN and PHLPP1 in patient samples is highly restricted to metastatic disease and tightly correlated to deletion of TP53 and PHLPP2. These data establish a conceptual framework for progression of PTEN mutant prostate cancer to life-threatening disease. |
