|  Help  |  About  |  Contact Us

Protein Coding Gene : Apex2 apurinic/apyrimidinic endonuclease 2

Primary Identifier  MGI:1924872 Organism  mouse, laboratory
Chromosome  X NCBI Gene Number  77622
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable DNA-(apurinic or apyrimidinic site) endonuclease activity; double-stranded DNA 3'-5' DNA exonuclease activity; and phosphoric diester hydrolase activity. Predicted to be involved in base-excision repair. Predicted to act upstream of or within DNA damage response and DNA recombination. Located in mitochondrial inner membrane and nucleus. Orthologous to human APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2).
PHENOTYPE: Hemizygous null male mice display mild growth retardation, thymic atrophy, reduced white blood cell counts, and a slight decrease in red blood cell count. [provided by MGI curators]
  • synonyms:
  • C430040P13Rik,
  • apurinic/apyrimidinic endonuclease 2,
  • RIKEN cDNA C430040P13 gene,
  • Apex2,
  • Ape2

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For