| Primary Identifier | MGI:1921620 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 74370 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including 14-3-3 protein binding activity; enzyme binding activity; and protein kinase regulator activity. Involved in several processes, including TORC1 signaling; negative regulation of insulin secretion; and positive regulation of cell differentiation. Predicted to be located in several cellular components, including cytoplasmic stress granule; lysosome; and nucleoplasm. Predicted to be part of TORC1 complex. Predicted to be active in lysosomal membrane. Predicted to colocalize with dendrite and neuronal cell body. Is expressed in several structures, including cardiovascular system; early conceptus; endocrine gland; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1). PHENOTYPE: Homozygous mutation of this gene results in lethality prior to somitogenesis. Mice homozygous for a conditional allele activated in dendritic cells exhibit increased susceptibility to induced colitis and expansion of certain populations of dendritic cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
