| First Author | Weir HJ | Year | 2012 |
| Journal | PLoS One | Volume | 7 |
| Issue | 11 | Pages | e48225 |
| PubMed ID | 23139766 | Mgi Jnum | J:194865 |
| Mgi Id | MGI:5474922 | Doi | 10.1371/journal.pone.0048225 |
| Citation | Weir HJ, et al. (2012) CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease. PLoS One 7(11):e48225 |
| abstractText | Progressive mitochondrial dysfunction contributes to neuronal degeneration in age-mediated disease. An essential regulator of mitochondrial function is the deacetylase, sirtuin 3 (SIRT3). Here we investigate a role for CNS Sirt3 in mitochondrial responses to reactive oxygen species (ROS)- and Alzheimer's disease (AD)-mediated stress. Pharmacological augmentation of mitochondrial ROS increases Sirt3 expression in primary hippocampal culture with SIRT3 over-expression being neuroprotective. Furthermore, Sirt3 expression mirrors spatiotemporal deposition of beta-amyloid in an AD mouse model and is also upregulated in AD patient temporal neocortex. Thus, our data suggest a role for SIRT3 in mechanisms sensing and tackling ROS- and AD-mediated mitochondrial stress. |
