| First Author | Geng W | Year | 2020 |
| Journal | Biomed Res Int | Volume | 2020 |
| Pages | 6848450 | PubMed ID | 32149120 |
| Mgi Jnum | J:299902 | Mgi Id | MGI:6490799 |
| Doi | 10.1155/2020/6848450 | Citation | Geng W, et al. (2020) Electroacupuncture Pretreatment Alleviates Cerebral Ischemia-Reperfusion Injury by Increasing GSK-3beta Phosphorylation Level via Adenosine A1 Receptor. Biomed Res Int 2020:6848450 |
| abstractText | Objective: To observe the effect of adenosine A1 receptor in the hippocampus of mice on GSK-3beta phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Alpha1 receptor mediating cerebral ischemia-reperfusion injury. Method: The model of middle cerebral artery occlusion (MCAO) was established and grouped into electroacupuncture pretreatment group (EA group), MCAO group, and sham-operated group (Sham group). The neurobehavioral manifestation, the volume of cerebral infarction, and its related protein changes in mice in each group were observed. Then, adenosine Alpha1 receptor antagonist and agonist were injected intraperitoneally to observe the effects of A1 receptor on the phosphorylation level of GSK-3beta phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Alpha1 receptor mediating cerebral ischemia-reperfusion injury. Results: (1) Compared with the MCAO group (24 hours after reperfusion), the infarct size in the EA group decreased significantly, and the Garcia neurological score and phosphorylation level of GSK-3beta phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Alpha1 receptor mediating cerebral ischemia-reperfusion injury. beta phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Alpha1 receptor mediating cerebral ischemia-reperfusion injury. beta phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Alpha1 receptor mediating cerebral ischemia-reperfusion injury. Conclusions: Electroacupuncture pretreatment can increase GSK-3beta phosphorylation level via activating A1 receptor, to protect neurons in ischemia-reperfusion injury.beta phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Alpha1 receptor mediating cerebral ischemia-reperfusion injury. |
