| Primary Identifier | MGI:1341787 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 193034 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables calcium channel activity; identical protein binding activity; and temperature-gated ion channel activity. Involved in detection of temperature stimulus involved in sensory perception of pain and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception; diet induced thermogenesis; and fever generation. Located in neuron projection and plasma membrane. Is expressed in central nervous system; cochlea; dorsal root ganglion; and eye. Human ortholog(s) of this gene implicated in migraine. Orthologous to human TRPV1 (transient receptor potential cation channel subfamily V member 1). PHENOTYPE: Homozygous mutant mice demonstrate abnormal nociception, abnormal anxiety- and conditioning-related behaviors, increased sensitivity to DOCA-salt-induced renal damage, resistance to diet-induced obesity, altered taste sensitivity, and impaired febrile response. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
