| First Author | Balogh SA | Year | 1999 |
| Journal | Brain Res | Volume | 836 |
| Issue | 1-2 | Pages | 38-48 |
| PubMed ID | 10415403 | Mgi Jnum | J:57138 |
| Mgi Id | MGI:1343893 | Doi | 10.1016/s0006-8993(99)01586-3 |
| Citation | Balogh SA, et al. (1999) A behavioral and neuroanatomical assessment of an inbred substrain of 129 mice with behavioral comparisons to C57BL/6J mice. Brain Res 836(1-2):38-48 |
| abstractText | The inbred 129 substrains have been characterized as poor learners that display hypoplasia of the corpus callosum. However, they are used extensively as a source of embryonic stem (ES) cells for creating mice carrying altered copies of a targeted gene ('knockout mice'). The present research investigated callosal agenesis and behavior in the 129/SvEvTac substrain and compared their behavior to that of C57BL/6J mice. In addition, the degree to which callosal agenesis affected behavior was assessed. Nearly 80% of 129/SvEvTac mice in the current sample exhibited callosal hypoplasia, although this was not subsequently found to be associated with any measure of cognition. They learned the Morris maze and a non-spatial pattern discrimination task, though at a level inferior to C57BL/6J mice. They were unable to learn shuttlebox avoidance or the Lashley III maze. The only measure on which they performed better than C57BL/6J mice was a simple water escape task. Thus, 129/SvEvTac mice, in addition to displaying aberrant neuroanatomy, perform poorly on many behavioral tasks, resulting in potential interpretational difficulties. Copyright 1999 Elsevier Science B.V. |
