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Publication : The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells.

First Author  Fujishita T Year  2022
Journal  Cancer Res Volume  82
Issue  22 Pages  4179-4190
PubMed ID  36066360 Mgi Jnum  J:330910
Mgi Id  MGI:7384766 Doi  10.1158/0008-5472.CAN-22-1369
Citation  Fujishita T, et al. (2022) The cAMP/PKA/CREB and TGFbeta/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells. Cancer Res 82(22):4179-4190
abstractText  SIGNIFICANCE: This study identifies signaling pathways essential for maintaining the stemness and metastatic potential of colorectal cancer cells and proposes CREB as a therapeutic target in metastatic colorectal cancer.
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