| First Author | Bell RG | Year | 1984 |
| Journal | Infect Immun | Volume | 45 |
| Issue | 1 | Pages | 273-5 |
| PubMed ID | 6429049 | Mgi Jnum | J:7483 |
| Mgi Id | MGI:55953 | Doi | 10.1128/iai.45.1.273-275.1984 |
| Citation | Bell RG, et al. (1984) A single gene determines rapid expulsion of Trichinella spiralis in mice. Infect Immun 45(1):273-5 |
| abstractText | In rats and some inbred mouse strains, one immune response, rapid expulsion, confers up to 95% protection against a challenge infection with Trichinella spiralis. Strain analysis in mice has shown that only three inbred strains, all originating from Swiss-line mice at the National Institutes of Health, Bethesda, Md., express rapid expulsion. Crosses between responder strain mice (NFR/N) and nonresponders (C3H/HeJ or B10 X BR) have indicated that rapid expulsion is dominant and autosomal (Bell et al., Exp. Parasitol. 53:301-314, 1982). In this study a segregation analysis of rapid expulsion in the F2 and backcross conformed to the Mendelian ratios expected of a single gene. This gene was not linked to the major histocompatibility complex (MHC) (chromosome 17) or the gene for albinism (c/c locus on chromosome 7). This locus has not previously been identified as conferring resistance to any infectious agent, and we have therefore designated the gene Ihe-1 (intestinal helminth expulsion 1). |
