| First Author | Sechler JM | Year | 1997 |
| Journal | J Immunol | Volume | 159 |
| Issue | 12 | Pages | 5766-8 |
| PubMed ID | 9550369 | Mgi Jnum | J:46308 |
| Mgi Id | MGI:1197546 | Doi | 10.4049/jimmunol.159.12.5766 |
| Citation | Sechler JM, et al. (1997) Genetic variation among 129 substrains: practical consequences. J Immunol 159(12):5766-8 |
| abstractText | We designed a series of experiments to define the role of IFN-gamma in cellular interactions mediating graft rejection by assessing the rejection of H-Y disparate grafts in both ligand and receptor knockout mice and their control inbred strain. In the course of these studies it became apparent that neither knockout strain is histocompatible with the putative control and that the putative control is not histocompatible with either knockout strain. In the profess of deducing why this might be so, it became apparent that the putative control is not an inbred strain of mouse. Thus, in the absence of rigorous genetic control, the utility of such knockout strains of mice for assessing the effects of cytokines and receptors in transplantation and autoimmunity is limited. |
