| First Author | Leonardi I | Year | 2022 |
| Journal | Cell | Volume | 185 |
| Issue | 5 | Pages | 831-846.e14 |
| PubMed ID | 35176228 | Mgi Jnum | J:322757 |
| Mgi Id | MGI:7259964 | Doi | 10.1016/j.cell.2022.01.017 |
| Citation | Leonardi I, et al. (2022) Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity. Cell 185(5):831-846.e14 |
| abstractText | Fungal communities (the mycobiota) are an integral part of the gut microbiota, and the disruption of their integrity contributes to local and gut-distal pathologies. Yet, the mechanisms by which intestinal fungi promote homeostasis remain unclear. We characterized the mycobiota biogeography along the gastrointestinal tract and identified a subset of fungi associated with the intestinal mucosa of mice and humans. Mucosa-associated fungi (MAF) reinforced intestinal epithelial function and protected mice against intestinal injury and bacterial infection. Notably, intestinal colonization with a defined consortium of MAF promoted social behavior in mice. The gut-local effects on barrier function were dependent on IL-22 production by CD4(+) T helper cells, whereas the effects on social behavior were mediated through IL-17R-dependent signaling in neurons. Thus, the spatial organization of the gut mycobiota is associated with host-protective immunity and epithelial barrier function and might be a driver of the neuroimmune modulation of mouse behavior through complementary Type 17 immune mechanisms. |
