| First Author | Thomason LA | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 15 | Pages | 2448-54 |
| PubMed ID | 23792157 | Mgi Jnum | J:198704 |
| Mgi Id | MGI:5499027 | Doi | 10.1016/j.febslet.2013.06.015 |
| Citation | Thomason LA, et al. (2013) Reactive astrocytes associated with plaques in TgCRND8 mouse brain and in human Alzheimer brain express phosphoprotein enriched in astrocytes (PEA-15). FEBS Lett 587(15):2448-54 |
| abstractText | To identify potential biomarkers associated with Alzheimer's disease (AD)-like neuropathologies in the murine brain, we conducted proteomic analyses of neocortices from TgCRND8 mice. Here we found that phosphoprotein enriched in astrocytes 15kDa (PEA-15) is expressed at higher levels in the neocortical proteomes from 6-month old TgCRND8 mice, as compared to non-transgenic mice. Immunostaining for PEA-15 revealed reactive astrocytes associated with the neocortical amyloid plaques in TgCRND8 mice and in post-mortem human AD brains. This is the first report of increased phosphoprotein enriched in astrocytes (PEA-15) expression in reactive astrocytes of an AD mouse model and human AD brains. |
