| First Author | Parrott MD | Year | 2015 |
| Journal | Neurobiol Aging | Volume | 36 |
| Issue | 1 | Pages | 90-9 |
| PubMed ID | 25212462 | Mgi Jnum | J:218434 |
| Mgi Id | MGI:5617458 | Doi | 10.1016/j.neurobiolaging.2014.08.013 |
| Citation | Parrott MD, et al. (2015) Whole-food diet worsened cognitive dysfunction in an Alzheimer's disease mouse model. Neurobiol Aging 36(1):90-9 |
| abstractText | Food combinations have been associated with lower incidence of Alzheimer's disease. We hypothesized that a combination whole-food diet containing freeze-dried fish, vegetables, and fruits would improve cognitive function in TgCRND8 mice by modulating brain insulin signaling and neuroinflammation. Cognitive function was assessed by a comprehensive battery of tasks adapted to the Morris water maze. Unexpectedly, a "Diet x Transgene" interaction was observed in which transgenic animals fed the whole-food diet exhibited even worse cognitive function than their transgenic counterparts fed the control diet on tests of spatial memory (p < 0.01) and strategic rule learning (p = 0.034). These behavioral deficits coincided with higher hippocampal gene expression of tumor necrosis factor-alpha (p = 0.013). There were no differences in cortical amyloid-beta peptide species according to diet. These results indicate that a dietary profile identified from epidemiologic studies exacerbated cognitive dysfunction and neuroinflammation in a mouse model of familial Alzheimer's disease. We suggest that normally adaptive cellular responses to dietary phytochemicals were impaired by amyloid-beta deposition leading to increased oxidative stress, neuroinflammation, and behavioral deficits. |
