| First Author | Wiedau-Pazos M | Year | 2009 |
| Journal | Neurobiol Aging | Volume | 30 |
| Issue | 1 | Pages | 14-21 |
| PubMed ID | 17604878 | Mgi Jnum | J:145819 |
| Mgi Id | MGI:3836114 | Doi | 10.1016/j.neurobiolaging.2007.05.015 |
| Citation | Wiedau-Pazos M, et al. (2009) Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice. Neurobiol Aging 30(1):14-21 |
| abstractText | Glycogen synthase kinase-3beta (GSK-3beta), a key component of the Wnt signaling pathway, has been recognized as an important tau kinase with a potential pathogenic role in dementia. We have previously shown that GSK-3beta-induced tau-hyperphosphorylation and Wnt-activation enhance tau-induced degeneration in Drosophila. Here, we demonstrate that Wnt-activation occurs prior to 3 months of age in the JNPL3 mouse model of frontotemporal dementia (FTD). We observed that GSK-3beta becomes associated with insoluble tau, concomitant with the increase in the downstream Wnt-pathway component beta-catenin. We demonstrate that this induces downstream Wnt signaling via the activation of nuclear transcription factors associated with beta-catenin, suggesting that Wnt-pathway activation is an early feature of the neurodegenerative process. |
