| First Author | Tognini P | Year | 2011 |
| Journal | Nat Neurosci | Volume | 14 |
| Issue | 10 | Pages | 1237-9 |
| PubMed ID | 21892154 | Mgi Jnum | J:179781 |
| Mgi Id | MGI:5303042 | Doi | 10.1038/nn.2920 |
| Citation | Tognini P, et al. (2011) Experience-dependent expression of miR-132 regulates ocular dominance plasticity. Nat Neurosci 14(10):1237-9 |
| abstractText | miR-132 is a CREB-induced microRNA that is involved in dendritic spine plasticity. We found that visual experience regulated histone post-translational modifications at a CRE locus that is important for miR-212 and miR-132 cluster transcription, and regulated miR-132 expression in the visual cortex of juvenile mice. Monocular deprivation reduced miR-132 expression in the cortex contralateral to the deprived eye. Counteracting this miR-132 reduction with an infusion of chemically modified miR-132 mimic oligonucleotides completely blocked ocular dominance plasticity. |
