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Protein Coding Gene : Zc3hav1 zinc finger CCCH type, antiviral 1
Primary Identifier  MGI:1926031 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  78781
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable several functions, including DEAD/H-box RNA helicase binding activity; NAD+-protein ADP-ribosyltransferase activity; and identical protein binding activity. Acts upstream of or within cellular response to exogenous dsRNA and positive regulation of type I interferon production. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in early conceptus; liver lobe; meninges; oocyte; and thymus primordium. Orthologous to human ZC3HAV1 (zinc finger CCCH-type containing, antiviral 1).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced murine leukemia virus replication efficiency in mouse embryonic fibroblasts. [provided by MGI curators]
  • synonyms:
  • 9130009D18Rik,
  • ZAP,
  • 2900058M19Rik,
  • RIKEN cDNA 1200014N16 gene,
  • MGI:1920298,
  • MGI:2441762,
  • RIKEN cDNA 9830115L13 gene,
  • RIKEN cDNA 2900058M19 gene,
  • MGI:1921567,
  • Zc3hav1,
  • 1200014N16Rik,
  • RIKEN cDNA 9130009D18 gene,
  • 9830115L13Rik,
  • zinc finger CCCH type, antiviral 1
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