| Primary Identifier | MGI:1098282 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 12279 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to be involved in cell killing; complement activation; and protein homooligomerization. Predicted to act upstream of or within complement activation, alternative pathway; complement activation, classical pathway; and killing of cells of another organism. Predicted to be located in plasma membrane. Predicted to be part of membrane attack complex. Predicted to be active in extracellular space. Is expressed in several structures, including brain; endocrine gland; genitourinary system; liver; and submandibular gland. Human ortholog(s) of this gene implicated in age related macular degeneration 15; complement component 9 deficiency; and opiate dependence. Orthologous to human C9 (complement C9). PHENOTYPE: Mice homozygous for a null allele exhibit impaired antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
