| First Author | Domanski P | Year | 1995 |
| Journal | FEBS Lett | Volume | 374 |
| Issue | 3 | Pages | 317-22 |
| PubMed ID | 7589562 | Mgi Jnum | J:29670 |
| Mgi Id | MGI:77195 | Doi | 10.1016/0014-5793(95)01094-u |
| Citation | Domanski P, et al. (1995) Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase. FEBS Lett 374(3):317-22 |
| abstractText | The Jak kinases and Stat transcription factors play a major role in signaling of various cytokines including IFN alpha. In this report we show a ligand-independent interaction between Tyk-2 and Jak-1 kinases. We also demonstrate that the Tyk-2 kinase forms a homodimer that has the ability to undergo intermolecular tyrosine phosphorylation. The formation of the Tyk-2 homodimer is independent of both tyrosine phosphorylation and the presence of the tyrosine kinase domain. |
