| First Author | van den Ouweland AM | Year | 1992 |
| Journal | Hum Genet | Volume | 90 |
| Issue | 1-2 | Pages | 144-6 |
| PubMed ID | 1330878 | Mgi Jnum | J:4287 |
| Mgi Id | MGI:52783 | Doi | 10.1007/BF00210759 |
| Citation | van den Ouweland AM, et al. (1992) The QM gene is X-linked and therefore not involved in suppression of tumorigenesis in Wilms' tumor. Hum Genet 90(1-2):144-6 |
| abstractText | Inactivation of one or more tumor-suppressor genes on the short arm of chromosome 11 is thought to play a role in the etiology of Wilms' tumor. A candidate gene, QM, was recently isolated by subtractive hybridization between a tumorigenic cell line (deleted for part of 11p) and a non-tumorigenic cell line (the tumorigenic cell line carrying an extra t(X;11)copy). We show here with an exon-specific polymerase chain reaction that the genomic homolog of the QM cDNA is located in the G6PD-color vision genes region in Xq28. No homologous sequences could be detected on 11p. Our experiments indicate that the QM gene is not involved in the suppression of Wilms' tumor. |
