| First Author | Takahashi S | Year | 1996 |
| Journal | J Clin Invest | Volume | 97 |
| Issue | 7 | Pages | 1597-604 |
| PubMed ID | 8601623 | Mgi Jnum | J:32235 |
| Mgi Id | MGI:79719 | Doi | 10.1172/JCI118584 |
| Citation | Takahashi S, et al. (1996) Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin Invest 97(7):1597-604 |
| abstractText | To investigate the respective roles of Th1 and Th2 cells in the pathogenesis of lupus-like autoimmune disease, we have analyzed the spontaneous and antigen-induced productions of IgG1 vs IgG2a and IgG3 subclasses in relation to the mRNA expression of INF-gamma (Th1 cytokine promoting IgG2a and IgG3 production), IL-4 (Th2 cytokine promoting IgG1 production), and IL-10 (Th2 cytokine) in CD4(+) T cells from lupus-prone MRL mice, For this purpose, two paired sets of MRL mice were chosen for the comparison of these parameters: (a) MRL-lpr/lpr (lpr for lymphoproliferation) and its recently described substrain with a prolonged survival, termed MRL-lpr/lpr.ll (ll for long lived) and (b) MRL male mice bearing the Yaa (Y- linked autoimmune acceleration) gene (MRL.Yaa) with an accelerated disease and their male counterparts lacking the Yaa gene, We demonstrate herein that the accelerated development of lupus-like autoimmune disease in MRL-lpr/ lpr and MRL.Yaa mice, as compared with MRL-lpr/lpr.ll and MRL-+/+ mice, respectively, was correlated with an enhanced expression of IFN-gamma vs IL-4 and IL-10 mRNA in CD4(+) T cells, which paralleled with an increase of spontaneous and foreign T cell-dependent antigen-induced productions of IgG2a and IgG3 vs IgG1 antibodies, These data suggest that an imbalance towards Th1 predominance may play a significant role in the acceleration of lupus- like autoimmune disease in MRL mice. |
