| Primary Identifier | IPR028674 | Type | Family |
| Short Name | LPP2 |
| description | Type 2 lipid phosphate phosphohydrolases (LPPs), formerly known as phosphatidic acid phosphatases (PAPs), are enzymes that catalyse the hydrolysis of a variety of lipid phosphate mono-esters, including lysophosphatidic acid (LPA), PA, diacylglycerolpyrophosphate, S1P and ceramide 1-phosphate (C-1-P). These are lipid mediators that exert complex effects on cell function through actions at cell surface receptors and on intracellular targets []. Type 2 LPPs are membrane bound enzymes, Mg2+-independent and N-ethylmaleimide-insensitive []. In humans, at least three genes coding for type 2 LPP enzymes have been identified (LPP1, LPP2 and LPP3).This entry represents LPP2, also known as PPAP2C []. PPAP2C is overexpressed in several cancers. In cancer cells, PPAP2C is involved in S-phase progression and is regulated by p53 []. |
