Primary Identifier | MGI:3522441 | Allele Type | Chemically induced (ENU) |
Gene | Clcn1 | Inheritance Mode | Recessive |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
description | The hind limbs of these mutants appear to lose function intermittently, i.e. both or one or the other hind leg may lag behind, or may be stretched to the side or front during movement. These episodes usually last less than a minute, and the mice then move around quite normally. Front limbs appear to be affected to a lesser degree. When the mutants are lifted up by their tail, the hind legs come together and point down- or backwards. The mutants do not breed and the colony has to be maintained through ovarian transplants. |
molecularNote | Complementation tests between NMF310 and Clcn1adr-mto were conducted. The results of heterozygous x heterozygous matings (NMF310 x BALB/cByj-Clcn1adr-mto2J), i.e. 6 affected mice in a total of 29 progeny, suggest that NMF310 represents an allele of Clcn1. |