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Publication : Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

First Author  Thomas DC Year  2017
Journal  J Exp Med Volume  214
Issue  4 Pages  1111-1128
PubMed ID  28351984 Mgi Jnum  J:241355
Mgi Id  MGI:5901952 Doi  10.1084/jem.20161382
Citation  Thomas DC, et al. (2017) Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity. J Exp Med 214(4):1111-1128
abstractText  The phagocyte respiratory burst is crucial for innate immunity. The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising gp91phox and p22phox subunits. Deficiency of either subunit leads to severe immunodeficiency. We describe Eros (essential for reactive oxygen species), a protein encoded by the previously undefined mouse gene bc017643, and show that it is essential for host defense via the phagocyte NAPDH oxidase. Eros is required for expression of the NADPH oxidase components, gp91phox and p22phox Consequently, Eros-deficient mice quickly succumb to infection. Eros also contributes to the formation of neutrophil extracellular traps (NETS) and impacts on the immune response to melanoma metastases. Eros is an ortholog of the plant protein Ycf4, which is necessary for expression of proteins of the photosynthetic photosystem 1 complex, itself also an NADPH oxio-reductase. We thus describe the key role of the previously uncharacterized protein Eros in host defense.
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