| First Author | Ismail AS | Year | 2011 |
| Journal | Proc Natl Acad Sci U S A | Volume | 108 |
| Issue | 21 | Pages | 8743-8 |
| PubMed ID | 21555560 | Mgi Jnum | J:171898 |
| Mgi Id | MGI:5002380 | Doi | 10.1073/pnas.1019574108 |
| Citation | Ismail AS, et al. (2011) {gamma}{delta} intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci U S A 108(21):8743-8 |
| abstractText | The mammalian gastrointestinal tract harbors thousands of bacterial species that include symbionts as well as potential pathogens. The immune responses that limit access of these bacteria to underlying tissue remain poorly defined. Here we show that gammadelta intraepithelial lymphocytes (gammadelta IEL) of the small intestine produce innate antimicrobial factors in response to resident bacterial 'pathobionts' that penetrate the intestinal epithelium. gammadelta IEL activation was dependent on epithelial cell-intrinsic MyD88, suggesting that epithelial cells supply microbe-dependent cues to gammadelta IEL. Finally, gammadelta T cells protect against invasion of intestinal tissues by resident bacteria specifically during the first few hours after bacterial encounter, indicating that gammadelta IEL occupy a unique temporal niche among intestinal immune defenses. Thus, gammadelta IEL detect the presence of invading bacteria through cross-talk with neighboring epithelial cells and are an essential component of the hierarchy of immune defenses that maintain homeostasis with the intestinal microbiota. |
