| First Author | Thompson JS | Year | 2001 |
| Journal | Science | Volume | 293 |
| Issue | 5537 | Pages | 2108-11 |
| PubMed ID | 11509692 | Mgi Jnum | J:71680 |
| Mgi Id | MGI:2150559 | Doi | 10.1126/science.1061965 |
| Citation | Thompson JS, et al. (2001) BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293(5537):2108-11 |
| abstractText | B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival. |
