| First Author | Yoshida T | Year | 2002 |
| Journal | Biosci Biotechnol Biochem | Volume | 66 |
| Issue | 5 | Pages | 963-9 |
| PubMed ID | 12092847 | Mgi Jnum | J:127501 |
| Mgi Id | MGI:3763827 | Doi | 10.1271/bbb.66.963 |
| Citation | Yoshida T, et al. (2002) Antigen presentation by Peyer's patch cells can induce both Th1- and Th2-type responses depending on antigen dosage, but a different cytokine response pattern from that of spleen cells. Biosci Biotechnol Biochem 66(5):963-9 |
| abstractText | The Th1 and Th2 preference induced by cells from the Peyer's patch (PP) and spleen (SPL) with various doses of an antigen was examined. The same splenic T cell receptor-transgenic CD4+ T cells were first incubated with PP or SPL cells in the presence of various doses of an antigen, and the cytokine response was observed after secondary stimulation. A Th2-type pattern was only obtained for primary stimulation at 10 microM of the antigen with PP cells, whereas a Th1 pattern was induced at both higher and lower concentrations. SPL cells in the presence of 0.1 to 1 microM of the antigen induced the secretion of Th2-type cytokines. Ten and 100 microM of the antigen plus SPL cells did not induce the release of a large quantity of cytokines. PP cells induced a different cytokine pattern at the antigen concentration that induced a similar level of T cell proliferation with SPL cells. Our findings suggest that the antigen-dose dependent development of Th1/Th2 cells is differentially modulated by the antigen-presentation function of cells in PP and SPL. |
