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Protein Coding Gene : Cnot8 CCR4-NOT transcription complex, subunit 8
Primary Identifier  MGI:1916375 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  69125
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in miRNA-mediated gene silencing by mRNA destabilization; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of cell population proliferation. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human CNOT8 (CCR4-NOT transcription complex subunit 8).
PHENOTYPE: Mice homozygous for a null allele exhibit lethality prior to E10.5. [provided by MGI curators]
  • synonyms:
  • expressed sequence AU015770,
  • AA536816,
  • 1810022F04Rik,
  • Cnot8,
  • MGI:2144376,
  • AU015770,
  • CCR4-NOT transcription complex, subunit 8,
  • expressed sequence AU043059,
  • MGI:2144436,
  • MGI:2142427,
  • 1500015I04Rik,
  • expressed sequence AA536816,
  • AU043059,
  • MGI:1923593,
  • RIKEN cDNA 1500015I04 gene,
  • RIKEN cDNA 1810022F04 gene
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