Primary Identifier | MGI:1918699 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 71449 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of cell cycle G1/S phase transition and negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. Is expressed in axial musculature; cochlear ganglion; inner ear; and submandibular gland primordium. Orthologous to human METTL13 (methyltransferase 13, eEF1A N-terminus and K55). PHENOTYPE: Mice heterozygous for a null allele exhibit infertility, bilateral cryptorchism, abnormal spermatogenesis, and increased Leydig cell number. [provided by MGI curators] |