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Protein Coding Gene : Mettl13 methyltransferase 13, eEF1A lysine and N-terminal methyltransferase

Primary Identifier  MGI:1918699 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  71449
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of cell cycle G1/S phase transition and negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. Is expressed in axial musculature; cochlear ganglion; inner ear; and submandibular gland primordium. Orthologous to human METTL13 (methyltransferase 13, eEF1A N-terminus and K55).
PHENOTYPE: Mice heterozygous for a null allele exhibit infertility, bilateral cryptorchism, abnormal spermatogenesis, and increased Leydig cell number. [provided by MGI curators]
  • synonyms:
  • Mettl13,
  • methyltransferase 13, eEF1A lysine and N-terminal methyltransferase,
  • 5630401D24Rik,
  • methyltransferase like 13,
  • MGI:7380592,
  • Eef1aknmt,
  • RIKEN cDNA 5630401D24 gene,
  • EEF1A lysine and N-terminal methyltransferase,
  • MGI:6277138

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2 Involved In Mutations

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Canonical gene --> Transcripts in specific strains.

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