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Protein Coding Gene : Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha

Primary Identifier  MGI:104878 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  19084
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables cAMP-dependent protein kinase inhibitor activity and protein kinase A catalytic subunit binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to glucagon stimulus; and positive regulation of insulin secretion. Acts upstream of or within cardiac muscle cell proliferation; mesoderm formation; and sarcomere organization. Located in several cellular components, including centrosome; multivesicular body; and sperm head-tail coupling apparatus. Part of cAMP-dependent protein kinase complex. Is active in cytosol and glutamatergic synapse. Is expressed in several structures, including brain; branchial arch; ganglia; sensory organ; and tooth. Used to study Carney complex; acrodysostosis; follicular thyroid carcinoma; and primary pigmented nodular adrenocortical disease. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha).
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality during organogenesis due to developmental patterning defects. Mice heterozygous for a null allele exhibit background sensitive infertility and increased tumor incidence. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-15266,
  • RIKEN cDNA 1300018C22 gene,
  • RIalpha,
  • Tse-1,
  • Prkar1a,
  • Tse1,
  • MGD-MRK-15269,
  • MGD-MRK-29031,
  • MGI:1914726,
  • protein kinase, cAMP dependent regulatory, type I, alpha,
  • 1300018C22Rik,
  • tissue specific extinction 1, of TAT

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Genome

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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Proteins

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Function

Mouse features --> Functions (GO terms)

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Interactions

38 Pathways

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Expression

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