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Allele : Tcf12<em1Jlr> transcription factor 12; endonuclease-mediated mutation 1, John Rubenstein
Primary Identifier  MGI:6200109 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Tcf12
Strain of Origin  CD-1 Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 mediated recombination deleted a 734 bp region (mm9; chr9:71822812-71823548) of an enhancer element (named hs623) in an intron of the locus. RTqPCR analysis determined that expression of the short isoforms (3 and 4) is reduced in the medial ganglionic eminence of homozygous mice but, expression of the long isoforms (1 and 2) is not reduced.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • hs623<Tm1>,
  • hs623<Tm1>
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