| First Author | Vokali E | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 538 |
| PubMed ID | 31988323 | Mgi Jnum | J:283733 |
| Mgi Id | MGI:6388049 | Doi | 10.1038/s41467-019-14127-9 |
| Citation | Vokali E, et al. (2020) Lymphatic endothelial cells prime naive CD8(+) T cells into memory cells under steady-state conditions. Nat Commun 11(1):538 |
| abstractText | Lymphatic endothelial cells (LECs) chemoattract naive T cells and promote their survival in the lymph nodes, and can cross-present antigens to naive CD8(+) T cells to drive their proliferation despite lacking key costimulatory molecules. However, the functional consequence of LEC priming of CD8(+) T cells is unknown. Here, we show that while many proliferating LEC-educated T cells enter early apoptosis, the remainders comprise a long-lived memory subset, with transcriptional, metabolic, and phenotypic features of central memory and stem cell-like memory T cells. In vivo, these memory cells preferentially home to lymph nodes and display rapid proliferation and effector differentiation following memory recall, and can protect mice against a subsequent bacterial infection. These findings introduce a new immunomodulatory role for LECs in directly generating a memory-like subset of quiescent yet antigen-experienced CD8(+) T cells that are long-lived and can rapidly differentiate into effector cells upon inflammatory antigenic challenge. |
