| First Author | Kodama L | Year | 2020 |
| Journal | Nat Neurosci | Volume | 23 |
| Issue | 2 | Pages | 167-171 |
| PubMed ID | 31873194 | Mgi Jnum | J:291788 |
| Mgi Id | MGI:6405520 | Doi | 10.1038/s41593-019-0560-7 |
| Citation | Kodama L, et al. (2020) Microglial microRNAs mediate sex-specific responses to tau pathology. Nat Neurosci 23(2):167-171 |
| abstractText | Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner. |
