| First Author | Sejimo S | Year | 2018 |
| Journal | Biochem Biophys Res Commun | Volume | 503 |
| Issue | 2 | Pages | 837-842 |
| PubMed ID | 29920240 | Mgi Jnum | J:272426 |
| Mgi Id | MGI:6280269 | Doi | 10.1016/j.bbrc.2018.06.084 |
| Citation | Sejimo S, et al. (2018) Scallop-derived plasmalogens attenuate the activation of PKCdelta associated with the brain inflammation. Biochem Biophys Res Commun 503(2):837-842 |
| abstractText | Activation of protein kinase C delta (PKCdelta) has been linked to the neuroinflammation but the relationship with the various neurodegenerative diseases including the Alzheimer's disease (AD) was mostly elusive. In the AD brains, the special phospholipids, ethanolamine plasmalogens (Pls), were found to be reduced and our previous study showed that these lipids possess neuroprotective and anti-inflammatory functions. In the present study, we could find that these lipids can significantly attenuate the microglial expression of PKCdelta in the neuroinflammation model and in the AD model mice brains. We also show an increase of PKCdelta in the human postmortem AD brains. In addition, we also report that scallop derived Pls (sPls) inhibited the p38MAPK and JNK protein expression which are involved in the expressional regulation of PKCdelta in the microglial cells. In addition, the lentiviral shRNA-mediated knockdown of PKCdelta attenuated the LPS-induced p65 (NF-kB) activation and inflammatory cytokine expression, suggesting that the PKCdelta can induce the inflammatory response which can be inhibited by the sPls. Taken together, our recent findings suggest that the sPls can attenuate the increased expression of PKCdelta associated with the neuro-inflammation in the murine brain. |
