| First Author | Branco-Price C | Year | 2012 |
| Journal | Cancer Cell | Volume | 21 |
| Issue | 1 | Pages | 52-65 |
| PubMed ID | 22264788 | Mgi Jnum | J:180281 |
| Mgi Id | MGI:5306056 | Doi | 10.1016/j.ccr.2011.11.017 |
| Citation | Branco-Price C, et al. (2012) Endothelial Cell HIF-1alpha and HIF-2alpha Differentially Regulate Metastatic Success. Cancer Cell 21(1):52-65 |
| abstractText | The hypoxia inducible transcription factors (HIFs) control many mediators of vascular response, including both angiogenic factors and small molecules such as nitric oxide (NO). In studying how endothelial HIF response itself affects metastasis, we found that loss of HIF-1alpha in endothelial cells reduces NO synthesis, retards tumor cell migration through endothelial layers, and restricts tumor cell metastasis, and that loss of HIF-2alpha has in each case the opposite effect. This results from differential regulation of NO homeostasis that in turn regulates vascular endothelial growth factor expression in an NO-dependent feedback loop. These opposing roles for the two HIF factors indicate that both they and endothelial cells regulate metastasis as malignancy progresses. |
