| First Author | Ma R | Year | 2021 |
| Journal | Front Immunol | Volume | 12 |
| Pages | 692509 | PubMed ID | 34335602 |
| Mgi Jnum | J:313999 | Mgi Id | MGI:6729391 |
| Doi | 10.3389/fimmu.2021.692509 | Citation | Ma R, et al. (2021) Nlrc3 Knockout Mice Showed Renal Pathological Changes After HTNV Infection. Front Immunol 12:692509 |
| abstractText | Hantaan virus (HTNV) infects humans and causes hemorrhagic fever with renal syndrome (HFRS). The development of well-characterized animal models of HFRS could accelerate the testing of vaccine candidates and therapeutic agents and provide a useful tool for studying the pathogenesis of HFRS. Because NLRC3 has multiple immunoregulatory roles, we investigated the susceptibility of Nlrc3(-/-) mice to HTNV infection in order to establish a new model of HFRS. Nlrc3(-/-) mice developed weight loss, renal hemorrhage, and tubule dilation after HTNV infection, recapitulating many clinical symptoms of human HFRS. Moreover, infected Nlrc3(-/-) mice showed higher viral loads in serum, spleen, and kidney than wild type C57BL/6 (WT) mice, and some of them manifested more hematological disorders and significant pathological changes within multiple organs than WT mice. Our results identify that HTNV infected Nlrc3(-/-) mice can develop clinical symptoms and pathological changes resembling patients with HFRS, suggesting a new model for studying the pathogenesis and testing of candidate vaccines and therapeutics. |
