| First Author | Arakaki N | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 18 | Pages | 3405-9 |
| PubMed ID | 17612527 | Mgi Jnum | J:123729 |
| Mgi Id | MGI:3719337 | Doi | 10.1016/j.febslet.2007.06.041 |
| Citation | Arakaki N, et al. (2007) Cell-surface H+-ATP synthase as a potential molecular target for anti-obesity drugs. FEBS Lett 581(18):3405-9 |
| abstractText | Here we show that the cell-surface expression of the alpha subunit of H(+)-ATP synthase is markedly increased during adipocyte differentiation. Treatment of differentiated adipocytes with small molecule inhibitors of H(+)-ATP synthase or antibodies against alpha and beta subunits of H(+)-ATP synthase leads to a decrease in cytosolic lipid droplet accumulation. Apolipoprotein A-I, which has been shown to bind to the ectopic beta-chain of H(+)-ATP synthase and inhibit the activity of cell-surface H(+)-ATP synthase, also was found to inhibit cytosolic lipid accumulation. These results suggest that the cell-surface H(+)-ATP synthase has a previously unsuspected role in lipid metabolism in adipocytes. |
