| First Author | Elson A | Year | 1996 |
| Journal | Proc Natl Acad Sci U S A | Volume | 93 |
| Issue | 23 | Pages | 13084-9 |
| PubMed ID | 8917548 | Mgi Jnum | J:36561 |
| Mgi Id | MGI:83989 | Doi | 10.1073/pnas.93.23.13084 |
| Citation | Elson A, et al. (1996) Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A 93(23):13084-9 |
| abstractText | We have generated a mouse model for ataxiatelangiectasia by using gene targeting to generate mice that do not express the Atm protein. Atm-deficient mice are retarded in growth, do not produce mature sperm, and exhibit severe defects in T cell maturation while going on to develop thymomas. Atm-deficient fibroblasts grow poorly in culture and display a high level of double-stranded chromosome breaks, Atm-deficient thymocytes undergo spontaneous apoptosis in vitro significantly more than controls. Atm- deficient mice then exhibit many of the same symptoms found in ataxiatelangiectasia patients and in cells derived from them. Furthermore, we demonstrate that the Atm protein exists as two discrete molecular species, and that loss of one or of bath of these can lead to the development of the disease. |
