| First Author | Huntsman MM | Year | 1999 |
| Journal | Science | Volume | 283 |
| Issue | 5401 | Pages | 541-3 |
| PubMed ID | 9915702 | Mgi Jnum | J:124675 |
| Mgi Id | MGI:3722220 | Doi | 10.1126/science.283.5401.541 |
| Citation | Huntsman MM, et al. (1999) Reciprocal inhibitory connections and network synchrony in the mammalian thalamus. Science 283(5401):541-3 |
| abstractText | Neuronal rhythmic activities within thalamocortical circuits range from partially synchronous oscillations during normal sleep to hypersynchrony associated with absence epilepsy. It has been proposed that recurrent inhibition within the thalamic reticular nucleus serves to reduce synchrony and thus prevents seizures. Inhibition and synchrony in slices from mice devoid of the gamma-aminobutyric acid type-A (GABAA) receptor beta3 subunit were examined, because in rodent thalamus, beta3 is largely restricted to reticular nucleus. In beta3 knockout mice, GABAA-mediated inhibition was nearly abolished in reticular nucleus, but was unaffected in relay cells. In addition, oscillatory synchrony was dramatically intensified. Thus, recurrent inhibitory connections within reticular nucleus act as 'desynchronizers.' |
