| Primary Identifier | IPR035471 | Type | Domain |
| Short Name | Amphiphysin-2_SH3 |
| description | Amphiphysin 2, also known as Bin1, is localized in many different tissues and may function in intracellular vesicle trafficking []. It plays a role in the organization and maintenance of the T-tubule network in skeletal muscle []. Mutations in Bin1 are associated with autosomal recessive centronuclear myopathy []. Bin1 contains an N-terminal BAR domain with an additional N-terminal amphipathic helix (an N-BAR) and a C-terminal SH3 domain.The SH3 domain of Bin1 forms transient complexes with actin, myosin filaments, and CDK5, to facilitate sarcomere organization and myofibre maturation []. It also binds dynamin and prevents its self-assembly []. |
