| First Author | Shai SY | Year | 1990 |
| Journal | Biochem Biophys Res Commun | Volume | 167 |
| Issue | 3 | Pages | 1128-33 |
| PubMed ID | 2157425 | Mgi Jnum | J:10403 |
| Mgi Id | MGI:58855 | Doi | 10.1016/0006-291x(90)90640-9 |
| Citation | Shai SY, et al. (1990) Genomic DNA 5' to the mouse and human angiotensin-converting enzyme genes contains two distinct regions of conserved sequence. Biochem Biophys Res Commun 167(3):1128-33 |
| abstractText | Genomic DNA 5' to the mouse and human genes encoding angiotensin-converting enzyme has been isolated and analyzed. A sequence comparison identifies two discrete regions of genomic DNA that are highly conserved. One region, found immediately 5' to the mouse and human ACE genes, is a GC rich segment that contains a TATA box and several potential Spl binding sites. The second conserved region is found further 5' and contains several potential regulatory cis elements including a possible glucocorticoid responsive element. These two regions of genomic DNA may influence the rate of mRNA transcription from the angiotensin-converting enzyme gene. |
