| First Author | Arts RJ | Year | 2013 |
| Journal | J Leukoc Biol | Volume | 93 |
| Issue | 2 | Pages | 209-15 |
| PubMed ID | 23108097 | Mgi Jnum | J:193765 |
| Mgi Id | MGI:5469534 | Doi | 10.1189/jlb.0312145 |
| Citation | Arts RJ, et al. (2013) TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors. J Leukoc Biol 93(2):209-15 |
| abstractText | TREM-1 is an important signaling receptor expressed on neutrophils and monocytes that plays an important role in systemic infections. Here, we review the intracellular signaling pathways that mediate the immunological effects of TREM-1. Because of the absence of signaling motifs, TREM-1 constitutively associates with DAP12 for induction of intracellular signals. After phosphorylation of DAP12, production of chemokines and cytokines is induced. Moreover, TREM-1 also modulates signaling pathways induced by known classes of PRRs, such as TLRs and NLRs. The exact mechanisms through which TREM-1 influences TLR and NLR pathways are still largely elusive. |
