| First Author | Mi W | Year | 2007 |
| Journal | Nat Genet | Volume | 39 |
| Issue | 12 | Pages | 1440-2 |
| PubMed ID | 18026100 | Mgi Jnum | J:130221 |
| Mgi Id | MGI:3771262 | Doi | 10.1038/ng.2007.29 |
| Citation | Mi W, et al. (2007) Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet 39(12):1440-2 |
| abstractText | Using transgenic mice expressing human cystatin C (encoded by CST3), we show that cystatin C binds soluble amyloid-beta peptide and inhibits cerebral amyloid deposition in amyloid-beta precursor protein (APP) transgenic mice. Cystatin C expression twice that of the endogenous mouse cystatin C was sufficient to substantially diminish amyloid-beta deposition. Thus, cystatin C has a protective role in Alzheimer's disease pathogenesis, and modulation of cystatin C concentrations may have therapeutic implications for the disease. |
