Primary Identifier | MGI:2386293 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Slpi |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Sequence extending from nucleotide -849 through nucleotide 46 was replaced with a neomycin selection cassette. Deletion of this region eliminated regulatory elements, sequence encoding the first 16 amino acids, and introduced a frameshift mutation. Northern blot analysis confirmed the absence of transcript in homozygous mutant mice. |