| First Author | Chen C | Year | 1996 |
| Journal | Behav Neurosci | Volume | 110 |
| Issue | 5 | Pages | 1177-80 |
| PubMed ID | 8919020 | Mgi Jnum | J:36925 |
| Mgi Id | MGI:84340 | Doi | 10.1037//0735-7044.110.5.1177 |
| Citation | Chen C, et al. (1996) Hippocampal lesions impair contextual fear conditioning in two strains of mice. Behav Neurosci 110(5):1177-80 |
| abstractText | Two different strains of mice, C57BL/6J and BALB/c, with hippocampal, cortical, or sham lesions, underwent contextual fear conditioning. In both strains, contextual fear, as measured by the freezing response, was significantly impaired in hippocampus-lesioned animals compared with sham control animals. Fear conditioning was not affected in the cortical-lesioned group. Moreover, there was a strain difference in fear conditioning: The C57BL/6J mice exhibited freezing more frequently than the BALB/c mice. Consistent with previous hippocampal lesion studies in rats, these results indicate that contextual fear conditioning in mice also requires the intact hippocampus. This study provides a basis for evaluating hippocampal synaptic mechanisms in relation to contextual fear conditioning in widely available gene knockout or transgenic mice. |
