| Primary Identifier | IPR037585 | Type | Family |
| Short Name | EIF4G3 |
| description | This entry represents eukaryotic translation initiation factor 4 gamma 3 (EIF4G3), a component of the eIF4F protein complex. The eIF4F complex varies according to the environment, but consists at least of EIF4A, EIF4E and EIF4G1/EIF4G3 []. The eIF4F complex is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome []. During viral infection, EIF4G3 may be cleaved to switch off host protein translation. Among the viral endopeptidases known to cleave EIF4G3 are: rhinovirus picornain 2A []and foot-and-mouth disease virus L-peptidase []. |
