| First Author | Hisatsune C | Year | 2007 |
| Journal | J Biol Chem | Volume | 282 |
| Issue | 51 | Pages | 37225-31 |
| PubMed ID | 17925404 | Mgi Jnum | J:129007 |
| Mgi Id | MGI:3768487 | Doi | 10.1074/jbc.M705641200 |
| Citation | Hisatsune C, et al. (2007) Abnormal Taste Perception in Mice Lacking the Type 3 Inositol 1,4,5-Trisphosphate Receptor. J Biol Chem 282(51):37225-37231 |
| abstractText | Inositol 1,4,5-trisphosphate receptor (IP(3)R) is one of the important calcium channels expressed in the endoplasmic reticulum and has been shown to play crucial roles in various physiological phenomena. Type 3 IP(3)R is expressed in taste cells, but the physiological relevance of this receptor in taste perception in vivo is still unknown. Here, we show that mice lacking IP(3)R3 show abnormal behavioral and electrophysiological responses to sweet, umami, and bitter substances that trigger G-protein-coupled receptor activation. In contrast, responses to salty and acid tastes are largely normal in the mutant mice. We conclude that IP(3)R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta2 to TRPM5 activation. |
