Type | MGI:General | Description | when mutant hematopoietic stem cells are transferred into immunodeficient rag-2 mutant recipients, most B-lineage cells are arrested at the CD43+ pro-B stage and only a small proportion of the pre-B cells become B220hiCD43lo; in the most severe cases, the CD43lo population is completely absent and no B220+IgM+ cells are detected |