Primary Identifier | MGI:95303 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 13681 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable double-stranded RNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Is expressed in several structures, including central nervous system; liver; lung; ovary; and sensory organ. Orthologous to human EIF4A1 (eukaryotic translation initiation factor 4A1). PHENOTYPE: Mice with loss of expression in developing B cells display near complete absence of splenic B cells. Loss of expression in mature B cells results in impaired development after activation. [provided by MGI curators] |