|  Help  |  About  |  Contact Us

Publication : Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium.

First Author  Miyoshi H Year  2017
Journal  EMBO J Volume  36
Issue  1 Pages  5-24
PubMed ID  27797821 Mgi Jnum  J:238856
Mgi Id  MGI:5824444 Doi  10.15252/embj.201694660
Citation  Miyoshi H, et al. (2017) Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. EMBO J 36(1):5-24
abstractText  Adaptive cellular responses are often required during wound repair. Following disruption of the intestinal epithelium, wound-associated epithelial (WAE) cells form the initial barrier over the wound. Our goal was to determine the critical factor that promotes WAE cell differentiation. Using an adaptation of our in vitro primary epithelial cell culture system, we found that prostaglandin E2 (PGE2) signaling through one of its receptors, Ptger4, was sufficient to drive a differentiation state morphologically and transcriptionally similar to in vivo WAE cells. WAE cell differentiation was a permanent state and dominant over enterocyte differentiation in plasticity experiments. WAE cell differentiation was triggered by nuclear beta-catenin signaling independent of canonical Wnt signaling. Creation of WAE cells via the PGE2-Ptger4 pathway was required in vivo, as mice with loss of Ptger4 in the intestinal epithelium did not produce WAE cells and exhibited impaired wound repair. Our results demonstrate a mechanism by which WAE cells are formed by PGE2 and suggest a process of adaptive cellular reprogramming of the intestinal epithelium that occurs to ensure proper repair to injury.
Quick Links:
Quick Links:


Publication --> Expression annotations



9 Bio Entities

Trail: Publication

0 Expression