| Primary Identifier | IPR006667 | Type | Domain |
| Short Name | SLC41_membr_dom |
| description | This entry represents the integral membrane region of SLC41 transporter proteins. SLC41 family of divalent cation transporters includes SLC41A1/2/3 from eukaryotes and MgtE from prokaryotes [, , , , ]. MgtE is the prokaryote homologue of SLC41A1 magnesium transporter which adopts a homodimeric architecture with five transmembrane domains in the C terminus and cytosolic N terminus domains [, ]. Bacterial family members have one copy of this region while archaeal and eukaryotic sequences have two. Mouse SLC41A2 has been shown to transport Mg2+ and a range of other divalent cations: Ba2+, Ni2+, Co2+, Fe2+, or Mn2+, but not Ca2+, Zn2+, or Cu2+ []. |
